目的 探讨急性脑梗死治疗中应用脑血管球囊成形支架置入术、氯吡格雷及阿替普酶溶栓联合疗法的效果。方法 选取我院2023年4月—2025年4月收治的90例急性脑梗死患者作为研究对象,采用随机分组法将其分为对比组与试验组,各45例。对比组患者接受氯吡格雷与阿替普酶溶栓联合疗法,试验组患者在对比组基础上接受脑血管球囊成形支架置入术治疗。比较两组患者治疗前后炎症因子水平、血液流变学指标、意识障碍程度、神经功能损伤情况及治疗效果。结果 治疗后,试验组患者超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平,全血比黏度（WBV）,血浆比黏度（PSV）,血小板聚集率（PAR）均低于对比组（P<0.05）;治疗后,试验组患者格拉斯哥昏迷量表（GCS）评分高于对比组,美国国立卫生研究院卒中量表（NIHSS）评分低于对比组（P<0.05）;试验组患者临床总有效率高于对比组（P<0.05）。结论 脑血管球囊成形支架置入术、阿替普酶溶栓及氯吡格雷联合方案能降低急性脑梗死患者的炎症反应程度,改善其血液流变学指标及意识障碍,减少神经功能损伤,提升治疗效果。

Objective To discussion the efficacy of using cerebral vascular balloon angioplasty stent implantation, clopidogrel, and alteplase thrombolysis combined therapy in the treatment of acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction admitted to our hospital from April 2023 to April 2025 were selected as the research subjects. They were randomly divided into a control group and an experimental group, with 45 cases in each group. The patients in the control group received clopidogrel and alteplase thrombolysis combined therapy, while the patients in the experimental group received cerebral vascular balloon angioplasty stent implantation therapy in addition to the control group. The levels of inflammatory factors, hemorheological indicators, degree of consciousness disorder, neurological function impairment, and treatment effect of the two groups before and after treatment were compared. Results After treatment, the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), whole blood viscosity (WBV), plasma specific viscosity (PSV), and platelet aggregation rate (PAR) in the experimental group were lower than those of the control group (P < 0.05); after treatment, the Glasgow coma scale (GCS) in the experimental group was higher than that of the control group, and the score of National Institutes of Health stroke scale (NIHSS) was lower than that of the control group (P < 0.05); the clinical total effective rate of the experimental group was higher than that of the control group (P < 0.05). Conclusion The combined therapy of cerebral vascular balloon angioplasty stent implantation, alteplase thrombolysis, and clopidogrel can reduce the inflammatory response degree of patients with acute cerebral infarction, improve their hemorheological indicators and degree of consciousness disorder, reduce neurological function impairment, and improve the treatment effect.