Objective To investigate the effect of risk screening combined with full-process body temperature management strategy on hypothermia prevention and coagulation function in acute trauma patients. Methods A total of 92 patients with acute trauma who attended the emergency department of our hospital from January 2023 to June 2024 were enrolled as the research subjects and divided into two groups by random sampling, with 46 cases in each group. Patients in the control group received routine acute trauma first aid care, while those in the observation group received risk screening combined with the whole process of temperature management on the basis of the control group. The incidence of hypothermia and chills, the duration of hypothermia and coagulation indicicators before and after the intervention were compared between the two groups. Results The incidence of hypothermia and chills in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05), and the duration of hypothermia in the observation group was shorter than that in the control group (P < 0.05).After the intervention the differencs in prothrombin time (PT) and activated partial thromboplastin time in the observation group were shorter than those in the control group (P < 0.05). Conclusion The implementation of risk screening combined with full-process body temperature management strategy in acute trauma patients can effectively improve the coagulation function, prevent the occurrence of hypothermia and chills, and shorten the duration of hypothermia.